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doi: 10.2527/1999.7782172x 146 BurkRFNorsworthyBKHillKEMotleyAKByrneDW

Edited by Professor Anastasis Stephanou Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

Therefore, at any point during development any progress towards the diagnostic requirements can be tracked, modified or enhanced as the design progresses

It produces proinflammatory cytokines and chemokines like interleukin (IL)-12 and tumor necrosis factor alpha (TNF), induces further inflammation and IFN release, and attracts neutrophils, natural killer (NK) cells, and lymphocytes to the site of infection (135)